Research Projects

Antibiotic resistant bacteria - a growing problem.

The bacterium Streptococcus pneumoniae is a major cause of common diseases such as ear infections, sepsis, pneumonia and meningitis. Usually, pneumococcal infections are treated with antibiotic therapy, but the increasing prevalence of resistance has now become a worldwide problem. In this project, mechanisms behind the development and spread of resistant pneumococci are investigated. Contact: Diana Karlsson 

Staphylococcus aureus - the golden killer

Staphylococcus aureus is a common human pathogen, which causes several life-threatening infections. The ability to cause disease is dependent of virulence factors, which are produced by the bacteria. The activity of the genes encoding the different virulence factors is controlled by different regulators. Using a systems biology approach, we try to map how the different regulators affect each other and finally the production of virulence factors. Contact: Erik Gustafsson 

Biofilms - bacterial cities

Biofilms are bacterial communities consisting of bacteria associated with different structures, most commonly in water. This is a very huge problem in medical care. The biofilm structure range from flat homogenous layers, to more complex structures often composed of mushroom-like colonies (microcolonies) interspersed with open water channels. In this project computer models of biofilms are constructed to be able to simulate the formation of biofilms. Contact: Magnus Fagerlind 

Bacterial vaginosis - a dangerous charge

Bacterial vaginosis is a complex syndrome where the normal bacterial flora in the vagina has been disturbed. The disturbance might result in pre-term labour or miscarriage for pregnant women. In this project the bacteria that are causing bacterial vaginosis are studied to examine if there is a connection between this syndrome and colonization of Streptococcus agalactiae. Contact: Henrik Ericson 

Sepsis – early diagnostics for lower mortality

Today the routine laboratory techniques used for diagnosis of sepsis are slow which results in a lag period from sampling to knowledge about what caused the sepsis and what kind of antibiotic to give to the patient. During this lag period the mortality in sepsis increases abruptly. The aim of this project is to develop molecular methods to see if the bacterium can be detected at an earlier stage and look into its resistance pattern and virulence factors. Anna-Karin Pernestig 

Mathematical modeling of T-cells

T helper cells are central in regulating the immune system as they regulate B cells to produce antibodies and activate cytotoxic T cells to eliminate infected target cells. This project aims to clarify how T helper cells can be activated and inhibited in collaboration with Simon Davis, University of Oxford. Read more. Contact: Andreas Jansson 

Mathematical modeling of Ulcerative Colitis

The research of inflammatory bowel disease (IBD) has advanced without quantitative approaches, making the interpretation of the data extremely difficult from a systemic point of view. We therefore aim to apply a systems biology approach, which is an emerging area that has arisen from the need to handle and interpret large complex datasets by combining mathematical models with experimental data. A quantitative understanding of how IBD arise and propagates will enable computational simulation of the disease state. Read more. Contact: Andreas Jansson

Informatsion fusion of stem cell development

In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidates. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely and triggered to differentiate into any cell type. The current project aims at making use of these two attributes to develop in vitro assays for predicting toxicity of pharmaceutical compounds. Read more. Contact: Jane Synnergren  

 

Pea root rot - identification at the molecular level

Root rot is often considered to be the most persistent and destructive disease of pea (Pisum sativum). The disease can be caused by one or several common soil borne fungi. Early and accurate detection of these plant pathogens are important for effective plant disease management. The aim of this project is to develop molecular diagnostic methods for effective and quantitative identification of the pathogens that causes root rot in pea. Read more. Contact: Maria Algerin 


Uppdaterad: 2011-05-10